Lesson 11: Sleep Apnea, Pulmonary Hypertension and Lung Cancer

Sleep-disordered breathing, right-heart vascular disorders, malignancy red flags and prevention.

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Course 04: Respiratory Medicine and Infectious Disease

Lesson 11 of 14. Explore the diagnostic and management frameworks, work through the case, and finish the linked 10-question practice set. Urgent presentations require an emergency-care pathway and review of local professional scope.

Obstructive sleep apnea (OSA)

  • Snoring, witnessed apnea, choking, daytime sleepiness, resistant hypertension and impaired concentration raise OSA suspicion; assess sleep and safety consequences.
  • Confirm diagnosis with appropriate sleep testing; wearable snore reports do not establish severity.
  • CPAP, weight-related strategies where appropriate, positional therapy and specialist alternatives should be personalized; review adherence and mask tolerability.

Pulmonary hypertension

  • Progressive dyspnea, presyncope, edema, elevated JVP and loud pulmonic component of S2 may reflect pulmonary hypertension; causes include left heart and chronic lung disease.
  • Echo can estimate right-heart pressure strain but right-heart catheterization establishes hemodynamic diagnosis when indicated.
  • Avoid treating all pulmonary hypertension with pulmonary arterial hypertension-specific drugs; classification and specialty care matter.

Lung cancer assessment

  • Persistent or unexplained cough, hemoptysis, weight loss, unilateral wheeze, recurrent same-site pneumonia or imaging nodule requires appropriate investigation.
  • Lung cancer screening in asymptomatic high-risk individuals differs from diagnostic imaging in a symptomatic person; use applicable provincial screening criteria.
  • Assess smoking history in pack-years, prior exposure and family preferences; discuss false positives, overdiagnosis and benefits in screening conversations.

Integrated prevention and function

  • Smoking/vaping cessation support, occupational controls, vaccines, exercise and symptom-directed referral are shared prevention priorities.
  • Monitor driving and public safety when significant untreated sleepiness is present and follow local standards.
  • Be attentive to stigma, accessibility, health literacy and financial barriers to CPAP or investigations.

Applied clinical case

A 59-year-old with 40 pack-years has new hemoptysis, 8 kg weight loss and a persistent focal opacity on chest radiography.

Show model clinical reasoning and disposition

This is a diagnostic work-up for possible lung malignancy, not an asymptomatic screening situation. Arrange expedited chest CT and specialist assessment in the appropriate pathway.

Clinical self-check

  1. What confirms OSA?
  2. Why does screening differ from symptom investigation?
  3. What test confirms pulmonary-hypertension hemodynamics?

Current guidance and further learning

Downloadable learning materials

Practice lesson questions